Introduction to Statistics Through Resampling Methods and Microsoft Office Excel

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Resampling Stats for Excel is an add-in for Excel for Windows that facilitates bootstrapping, permutation and simulation procedures with data in Excel. The latest release, version 4. The resampling operation will be repeated thousands or tens of thousands of times, and each time the value of your statistic of interest will be recorded. Comes with a page user guide available available online ; works with English language versions of Excel for Windows.

Excel for Statistics 1--Introduction

Excel add-in screenshots and features. A step-by-step example using the Excel add-in. Download a 1-year trial version of the Excel add-in Yes — a whole year! Other Features of the Resampling Stats Excel add-in version 4. Different methods for calculating reference intervals Estimating reference intervals means dealing with uncertainties and probabilities.

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Figure 2. Percentiles A proper start when calculating reference intervals is to estimate the observation s corresponding to 2. Subsequent randomly drawn reference values Drag the small quadrant in the lower right corner of cell C1 to column AG83 thereby creating 30 samples, each of 83 random observations from the original observations.

Calculating the 0. Calculate the medians of the random sample estimates of the population percentiles Lastly calculate the median of the samples estimates of the population 0. Table 1 Detailed instructions to create the calculation sheet. Step Instruction Input the data from the reference persons In column A.

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It is crucial for this application that you make at least 39 random picks. Calculate the 2. Figure 3. Conclusion Resampling methods are recommended by IFCC and are widely available in software for handling reference values 5 , 19 - 24 but not as yet as yet a part of the CLSI guideline Footnotes None declared.

References 1. Establishment and use of normal values. Scand J Clin Invest. The theory of reference values: an unfinished symphony. Clin Chem Lab Med. Murphy EA. The normal, and the perils of the sylleptic argument. Perspect Biol Med. Reference Values in Laboratory Medicine. Solberg HE. The IFCC recommendation on estimation of reference intervals. The RefVal program. Statistical bases of reference values in laboratory medicine. New York: M. Dekker; The theory of reference values Part 5. Statistical treatment of collected reference values. Determination of reference limits.

J Clin Chem Clin Biochem. Need for revisiting the concept of reference values. Horowitz GL. Establishment and Use of Reference Values. Tietz textbook of Clinical Chemistry and Molecular Diagnostics. Fifth Edition ed. Louis: Elsevier; Efron B, Tibshirani R. An introduction to the bootstrap.

Good PI. Resampling methods: a practical guide to data analysis. Christie D. Resampling with Excel. Teach Stat. The statistical theory of reference values. Part 5. Clin Chim Acta. Hyndman RJ, Fan Y.

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Sample Quantiles in Statistical Packages. Am Stat. Accessed May 17 RefVal: a program implementing the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. Comput Methods Programs Biomed. Analyse-it Software L.

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Analyse-IT Linnet C. Kenny D, Solberg HE. RefVal for windows--migrating to the Windows environment with the help of Visual Basic. Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel. Vet Clin Pathol.

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Statistical-Data Analysis in the Computer-Age. Jones HL.

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Investigating the properties of a sample mean by employing random subsample means. The theory of reference values. Statistical treatment of collected reference values determination of reference limits. Linnet K. Nonparametric estimation of reference intervals by simple and bootstrap-based procedures.

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Stat Sci. Approved recommendation on the theory of reference values. The comparison of parametric and nonparametric bootstrap methods for reference interval computation in small sample size groups.

Accredit Qual Assur. Non-parametric estimation of reference intervals in small non-Gaussian sample sets. On the Numerical Accuracy of Spreadsheets. J Stat Softw. On the accuracy of statistical procedures in Microsoft Excel Comput Stat Data Anal. Melard G. Comput Stat. Support Center Support Center.